Lewyt College of Veterinary Medicine

ABOUT

José Godoy, DVM, Ph.D.

Associate Professor of Veterinary Physiology

Email:Jose.Godoy@liu.edu

Dr. José Godoy obtained his veterinary degree from the School of Veterinary Medicine, Catholic University of Temuco, Chile, in 2000. After working for approximately 2 years as a practicing veterinarian in his native country, he traveled to Germany where he started his academic career in 2002. During 2003-2007 he conducted research on transport proteins (SLC10 and ABC carriers) at the Institute for Veterinary Pharmacology and Toxicology, Justus Liebig University of Giessen, Germany, obtaining his PhD (Dr. med. vet.). During that time, Dr. Godoy also completed a special training on molecular biology at the Deutsche Forschungsgemeinschaft (DFG) Graduate School of Molecular Veterinary Medicine. After obtaining his doctoral degree, Dr. Godoy worked as a Postdoctoral fellow at the Institute for Cytobiology of the Philipps University in Marburg, Germany from 2007 to 2011, focusing his research on the role of redox proteins and redox protein signaling in disease. In 2011, Dr. Godoy moved to Austria to join, as a senior lecturer, the Institute of Physiology and Pathophysiology of the University of Veterinary Medicine in Vienna. From 2016 until May 2019, Dr. Godoy held an Assistant Professor position in Veterinary Physiology at the Ross University School of Veterinary Medicine in Saint Kitts, West Indies. He joined Long Island University College of Veterinary Medicine in May 2019.

Dr. Godoy’s current research focuses on the role of redox proteins of the thioredoxin family in ischemic pathologies as well as in age-related diseases. Other research interests include oxidative stress in general and the application of redox proteins as oxidative stress markers of veterinary disease. Dr. Godoy is a member of the American Physiological Society and of the Society of Free Radical Biology and Medicine. In addition to his research background, Dr. Godoy has 12 years of teaching experience and has been the recipient of prestigious teaching awards.  

Publications - (selected manuscripts)

  • Hanschmann EM, Wilms C, Falk L, Holubiec MI, Mennel S, Lillig CH, Godoy JR. Cytosolic glutaredoxin 1 is upregulated in AMD and controls retinal pigment epithelial cells proliferation via β-catenin. Biochemical and Biophysical Research Communications Volume 618, 2022, Pages 24-29.
  • Loreto Palacio P, Godoy JR, Aktas O, Hanschmann EM. Changing Perspectives from Oxidative Stress to Redox Signaling—Extracellular Redox Control in Translational Medicine. Antioxidants 11 (6), 1181.
  • Godoy JR, Watson G, Raspante C, Illanes O. An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury. J. Vis. Exp. 2021 doi: 10.3791/62749.
  • Godoy JR, Pittrich S, Slavic S, Lillig CH, Hanschmann EM, Erben RG. Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response. Histochem Cell Biol 2020.https://doi.org/10.1007/s00418-020-01939-w
  • Urbainsky C, Nölker R, Imber M, Lübken A, Mostertz J, Hochgräfe F, Godoy JR, Hanschmann EM, Lillig CH. Nucleoredoxin-Dependent Targets and Processes in Neuronal Cells. Oxid Med Cell Longev.2018 Nov 21;2018:4829872 https://www.hindawi.com/journals/omcl/2018/4829872/
  • Zwolanek D, Satué M, Proell V, Godoy JR, Odörfer KI, Flicker M, Hoffmann SC, Rülicke T, Erben RG. Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model. JCI Insight. 2017 Oct 19;2(20) https://insight.jci.org/articles/view/87322
  • Hanschmann EM, Godoy JR, Berndt C, Hudemann C, Lillig CH. Thioredoxins, glutaredoxins, and peroxiredoxins - molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal2013 Nov 1;19(13):1539-605 http://online.liebertpub.com/doi/abs/10.1089/ars.2012.4599
  • Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A, Lillig CH, Berndt C. Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci U S A2011 Dec 20;108(51):20532-7 http://www.pnas.org/content/108/51/20532.long
  • Godoy JR, Oesteritz S, Hanschmann EM, Ockenga W, Ackermann W, Lillig CH. Segment-specific overexpression of redoxins after renal ischemia and reperfusion: protective roles of glutaredoxin 2, peroxiredoxin 3, and peroxiredoxin 6. Free Radic Biol Med2011 Jul 15;51(2):552-61
  • Hoffmann B, Uzarska MA, Berndt C, Godoy JR, Haunhorst P, Lill R, Lillig CH, Mühlenhoff U. The multi-domain thioredoxin-monothiol glutaredoxins represent a distinct functional group. Antioxid Redox Signal2011 Jul 1;15(1):19-30
  • Godoy JR, Funke M, Ackermann W, Haunhorst P, Oesteritz S, Capani F, Elsässer HP, Lillig CH. Redox atlas of the mouse: Immunohistochemical detection of glutaredoxin-, peroxiredoxin-, and thioredoxin-family proteins in various tissues of the laboratory mouse. Biochim Biophys Acta2011 1810(1):2-92
  • Hanschmann EM, Lönn ME, Schütte LD, Funke M, Godoy JR, Eitner S, Hudemann C, Lillig CH. Both thioredoxin 2 and glutaredoxin 2 contribute to the reduction of the mitochondrial 2-Cys peroxiredoxin Prx3. J Biol Chem2010 285(52):40699-705 http://www.jbc.org/content/285/52/40699.long
  • Mühlenhoff U, Molik S, Godoy JR, Uzarska MA, Richter N, Seubert A, Zhang Y, Stubbe J, Pierrel F, Herrero E, Lillig CH, Lill R. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metabolism2010 12(4):373-85 http://www.sciencedirect.com/science/article/pii/S1550413110002664
  • Haunhorst P, Berndt C, Eitner S, Godoy JR, Lillig CH. Characterization of the human monothiol glutaredoxin 3 (PICOT) as iron-sulfur protein. Biochem Biophys Res Commun2010 394(2):372-6 Hudemann C, Lönn ME, Godoy JR, Avval FZ, Capani F, Holmgren A, Lillig CH. Identification, expression patterns and characterization of mouse glutaredoxin 2 isoforms. Antioxid Redox Signal2009 11(1):1-14
  • Godoy JR, Fernandes C, Döring B, Beuerlein K, Petzinger E, Geyer J. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Eur J Cell Biol 2007 86(8):445-60
  • Geyer J, Döring B, Godoy JR, Leidolf R, Moritz A, Petzinger E. Frequency of the nt230(del4) MDR1 mutation in Collies and related dog breeds in Germany. J Vet Pharmacol Ther 2005 28(6): 545-51
  • Geyer J, Döring B, Godoy JR, Moritz A, Petzinger E. Development of a PCR-based diagnostic test detecting a nt230(del4) MDR1 mutation in dogs: verification in a moxidectin-sensitive Australian Shepherd. J Vet Pharmacol Ther 2005 28(1): 95-9