Lewyt College of Veterinary Medicine

ABOUT

Xiaolei Tang, MD, MSc, Ph.D

Professor, Physiology and Immunology

Email: Xiaolei.Tang@liu.edu

Dr. Tang holds an MD degree from the Wannan Medical College, Wuhu, China; a Master's in Immunology from Shanghai Medical College Fudan University; and a Ph.D. in Microbiology and Immunology from the University of Arizona.

Following medical school, Dr. Tang practiced medicine as a radiologist for two years at Huangshan City People's Hospital, Huangshan, Anhui Province, China. He then received a Master's degree in immunology in the Department of Immunology at Shanghai Medical College, Fudan University, where he continued as a lecturer for four years following graduation. Afterward, Dr. Tang obtained his Ph.D. in microbiology and immunology at the University of Arizona. He was then trained as a postdoctoral fellow in Dr. Vipin Kumar's research laboratory at Torrey Pines Institute for Molecular Studies in San Diego, California, where he remained for four years. Subsequently, he accepted a Research Associate position in the laboratory of Dr. Harvey Cantor at the Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. After 3.5 years at Harvard, Dr. Tag was a faculty member at the University of Texas, El Paso, Texas, for three years. Later, he decided to move to the Division of Regenerative Medicine, Department of Medicine, School of Medicine at Loma Linda University in California, first as an Assistant Research Professor and then as an Associate Research Professor for a total of 6 years. Dr. Tang joined the Long Island University College of Veterinary Medicine in September 2019. 

Dr. Tang has considerable teaching experience. He has taught undergraduate and graduate students, medical students, and other professional students. He has developed syllabi and directed courses mainly in immunology. Dr. Tang often emphasizes essential basic science concepts in clinically relevant scenarios that students can easily understand with different levels of knowledge. Dr. Tang strives to convey his passion for discipline and promote a learning environment that fosters student participation and small group discussion during his interactions with students. 

Research Interests:

Dr. Tang's research interests include regulatory T (Treg) and adult stem cells. In Treg cells, his laboratory investigates strategies that harness immune cells ex vivo and in vivo to enhance Treg cell function, specifically in tissues with immune disorders.


In adult stem cells, Dr. Tang’s laboratory focuses on studying technologies that enhance the functions of adult stem cells to improve tissue repair. Currently, his lab is investigating the role of de novo synthesized locally high concentrations of the active vitamin D and retinoic acid in the functions of intestinal stem cells (ISCs).


Publications - (selected manuscripts)

See Dr. Tang's complete publications here:

https://www.ncbi.nlm.nih.gov/myncbi/1J5cF1V0tC4ky/bibliography/public/

  • Nisar Ali Shaikh, Chenfan Liu, Yue Yin, David J Baylink, Xiaolei Tang. 1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells in Vitro and in Vivo. Submitted. May 2024.
  • Zhang Z, Zhao Q, Wang Z, Xu F, Liu Y, Guo Y, Li C, Liu T, Zhao Y, Tang X, Zhang J. Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis. Hepatol Commun. 2024 Mar 1;8(3). doi: 10.1097/HC9.0000000000000395. eCollection 2024 Mar 1. PubMed PMID: 38437062; PubMed Central PMCID: PMC10914236.
  • Nisar Ali Shaikh, Xiao-Bing Zhang, Maisa I. Abdalla, David J. Baylink, Xiaolei Tang. Zinc Enhances the Ability of Dendritic Cells Capable of De Novo Synthesizing High Active Vitamin D Concentrations to Indue CD4+ Regulatory T Cells. Crit Rev Immunol. 2024. 44(3):37-52.
  • Jiang L, Xu F, Li C, Liu T, Zhao Q, Liu Y, Zhao Y, Li Y, Zhang Z, Tang X, Zhang J. Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism. Cancer Med. 2023 Mar 7. doi: 10.1002/cam4.5759. Epub ahead of print. PMID: 36880364.
  • Inzana T, Tang X, Fuentealba C. Basic, clinical, and one-health research at Long Island University. Am J Vet Res. 2023 Feb 20:1. doi: 10.2460/ajvr.23.01.0004. Epub ahead of print. PMID: 36800300.
  • Nehme A, Ghahramanpouri M, Ahmed I, Golsorkhi M, Thomas N, Munoz K, Abdipour A, Tang X, Wilson SM, Wasnik S, Baylink DJ. Combination therapy of insulin-like growth factor I and BTP-2 markedly improves lipopolysaccharide-induced liver injury in mice. FASEB J. 2022 Aug;36(8):e22444. doi: 10.1096/fj.202200227RR. PMID: 35839071.
  • Ahmed ASI, Sheng MHC, Lau KW, Wilson SM, Wongworawat MD, Tang X, Ghahramanpouri M, Nehme A, Xu Y, Abdipour A, Zhang XB, Wasnik S, Baylink DJ. Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation. Am J Physiol Cell Physiol. 2022 Apr 6. doi: 10.1152/ajpcell.00413.2021. Epub ahead of print. PMID: 35385325.
  • Tang X, Chaturvedi VK. Preface: Regulatory T Cells in Immune Homeostasis. Crit Rev Immunol. 2022;42(2):v. doi: 10.1615/CritRevImmunol.2023047593. PMID: 37017284.
  • Xu Y, Baylink DJ, Cao H, Xiao J, Abdalla MI, Wasnik S, Tang X. Inflammation- and Gut-Homing Macrophages, Engineered to De Novo Overexpress Active Vitamin D, Promoted the Regenerative Function of Intestinal Stem Cells. Int J Mol Sci. 2021 September 1st;22(17):9516. doi: 10.3390/ijms22179516. PMID: 34502422; PMCID: PMC8430522. https://www.mdpi.com/1422-0067/22/17/9516.
  • Zhang B, Xu F, Wang K, Liu M, Li J, Zhao Q, Jiang L, Zhang Z, Li Y, Chen H, Zhang J, Tang X, Zhang J. BCAT1 knockdown-mediated suppression of melanoma cell proliferation and migration is associated with reduced oxidative phosphorylation. Am J Cancer Res. 2021;11(6):2670-2683. eCollection 2021. PubMed PMID: 34249421; PubMed Central PMCID: PMC8263658.
  • Munoz K, Wasnik S, Abdipour A, Bi H, Wilson SM, Tang X, Ghahramanpouri M, Baylink DJ. The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury. Int J Mol Sci. 2021 May 15th;22(10):5244. doi: 10.3390/ijms22105244. PMID: 34063554.
  • Yan B, Yang J, Xie Y, Tang X. Relationship between blood eosinophil levels and COVID-19 mortality. World Allergy Organ J. 2021 Mar;14(3):100521. doi: 10.1016/j.waojou.2021.100521. Epub 2021 Feb 11. PMID: 33589865; PMCID: PMC7877210. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877210/pdf/main.pdf. https://acaudio.com/publication/1269.
  • Xu Y, Payne K, Gia Pham, LH, Eunwoo P, Xiao J, Chi D, Lyu J, Campion R, Wasnik S, Jeong S, Tang X, Baylink DJ, Chen CS, Reeves M, Akhtari M, Mirshahidi S, Marcucci G, Cao H. A Novel Vitamin D Gene Therapy for Acute Myeloid Leukemia. Transl Oncol. 2020. September 18th;13(12). doi: 10.1016/j.tranon.2020.100869. Pdf: https://reader.elsevier.com/reader/sd/pii/S1936523320303612?token=ADBBBAE3CC605218C8D366A6F463FAC60DBD43EB996D2878AFE5826E05CC32044755FD438471CEEA0A1CB1FC5072603E.
  • Wasnik S, Tang X, Bi H, Abdipour A, E Carreon E, Sutjiadi B, Lyu J, Zhang J, Wilson S, Baylink DJ. IGF-1 Deficiency Rescue and Intracellular Calcium Blockade Improves Survival and Corresponding Mechanisms in a Mouse Model of Acute Kidney Injury. Int J Mol Sci. 2020 June 8th;21(11). doi: 10.3390/ijms21114095. PubMed PMID: 32521790. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312627/pdf/ijms-21-04095.pdf.
  • Wasnik S, Sharma I, Baylink DJ, Tang X. Vitamin D as a Potential Therapy for Multiple Sclerosis: Where Are We?. Int J Mol Sci. 2020 April 28th;21(9). doi: 10.3390/ijms21093102. Review. PubMed PMID: 32354174; PubMed Central PMCID: PMC7247155.
  • Bi H, Wasnik S, Baylink DJ, Liu C, Tang X. In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction. J Vis Exp. 2020 January 22nd;(155). doi: 10.3791/60585. PubMed PMID: 32065153.
  • Tang X, Kumar V. Advances in the Study of CD8+ Regulatory T Cells. Crit Rev Immunol. 2019;39(6):409-421. doi: 10.1615/CritRevImmunol.2020033260. PubMed PMID: 32421955.
  • Li CH*, Tang X*, Wasnik S, Wang X, Zhang J, Xu Y, Lau KW, Nguyen HB, Baylink DJ. Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis. BMC Infect Dis. 2019 December 2nd;19(1):1020. doi: 10.1186/s12879-019-4529-7. PubMed PMID: 31791247; PubMed Central PMCID: PMC6888965.
  • Wasnik S, Baylink DJ, Leavenworth J, Liu C, Bi H, Tang X. Towards Clinical Translation of CD8+ Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules. Int J Mol Sci. 2019 September 28th;20(19). doi: 10.3390/ijms20194829. Review. PubMed PMID: 31569411; PubMed Central PMCID: PMC6801908.
  • Wasnik S, Lakhan R, Baylink DJ, Rundle CH, Xu Y, Zhang J, Qin X, Lau KW, Carreon EE, Tang X. Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90+ skeletal stem cells in fracture sites. Sci Adv. 2019 Jul;5(7):eaaw2108. doi: 10.1126/sciadv.aaw2108. eCollection 2019 Jul. PubMed PMID: 31392271; PubMed Central PMCID: PMC6669009.
  • Xu Y, Cheng Y, Baylink DJ, Wasnik S, Goel G, Huang M, Cao H, Qin X, Lau KW, Chan C, Koch A, Pham LH, Zhang J, Li CH, Wang X, Berumen EC, Smith J, Tang X. In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis. J Immunol. 2019 June 15th;202(12):3447-3457. doi: 10.4049/jimmunol.1800018. Epub 2019 May 3rd. PubMed PMID: 31053627.

 Inventions:

• Xiaolei Tang, David J. Baylink, K.-H. William Lau, Michael Walter. A Method for Utilizing Engineered Dendritic Cells to Induce Gut-homing Regulatory T Cells and Treat Gut Inflammation. PCT/US2016/017610. LLUH case#14-021. Patent issued on March 3rd, 2020.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016130845&redirectedID=true
• Xiaolei Tang and David J. Baylink. Myelin Oligodendrocyte Glycoprotein-specific Peptide for the Treatment or Prevention of Multiple Sclerosis. PCT/US2017/040484. LLUH case#14-020.
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2018006067
• David J Baylink, Xiaolei Tang, Amir Abdi Pour, Samiksha Wasnik. Methods of treatment of a cytokine storm. LLUH case#20-025. Application# 17/928,972.
https://patentcenter.uspto.gov/applications/17928972?application=