Xiaolei Tang, MD, MSc, Ph.D

Associate Professor, Physiology and Immunology

Email: Xiaolei.Tang@liu.edu

Dr. Tang holds an MD degree from the Wannan Medical College, Wuhu, China; a Master degree in Immunology from Shanghai Medical College Fudan University; and a PhD degree in Microbiology and Immunology from the University of Arizona.

Following medical school, Dr. Tang practiced medicine as a radiologist for 2 years in Huangshan City People’s Hospital, Huangshan, Anhui province, China. After receiving his Master degree, he was appointed as a lecturer for 4 years in the Department of Immunology at Shanghai Medical College, Fudan University. After obtaining his PhD degree from the University of Arizona, Dr. Tang joined as a postdoctoral fellow Dr. Vipin Kumar’s research laboratory at Torrey Pines Institute for Molecular Studies in San Diego, California, where he remained for 4 years. Later he accepted a Research Associate position in the laboratory of Dr. Harvey Cantor at the Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. After 3.5 years at Harvard, he became a faculty member at the University of Texas, El Paso, Texas where he stayed for 3 years before joining as an Associate Research Professor, for a total of 6 years, the Division of Regenerative Medicine, Department of Medicine, School of Medicine at Loma Linda University in California. Dr. Tang joined the Long Island University College of Veterinary Medicine in September 2019.

Dr. Tang has considerable teaching experience. He has taught undergraduate and graduate students, medical students, and other professional students. He has developed syllabi and directed courses mainly in immunology. During his interactions with students, Dr. Tang strives to convey his passion for the discipline and to promote a learning environment that fosters student participation and small group discussion. Dr. Tang often emphasizes essential basic science concepts into clinically relevant scenarios that can be easily understood by students with different levels of knowledge.

Dr. Tang’s research interests include regulatory T (Treg) cells and the role of immune system in tissue repair. In the area of Treg cells, he is interested in the roles of 1,25(OH)2D (i.e. the active vitamin D metabolite) and retinoic acid (RA, i.e. the active vitamin A metabolite) in the induction of Treg cells and in the treatment of immune-mediated diseases through tissue-specific delivery of these two molecules. In addition, he is interested in the immune regulatory mechanisms of Qa-1(HLA-E in human)-restricted CD8 T cells. In the area of tissue repair, he is interested in the role of the immune system in stem cells. Such role may include stem cell recruitment, priming, and differentiation. The ultimate goals of the above studies are to develop novel therapies for diseases with improved safety and efficacy. Dr. Tang has consistently received extramural funding for his research from National Institute of Health (NIH), Department of Defense (DoD), and the National Multiple Sclerosis Society (NMSS).

Publications - (selected manuscripts)

  • Bi H, Wasnik S, Baylink DJ, Liu C, Tang X. A method for in vivo augmentation of the induction of gut-homing regulatory T cells. J Vis Exp. 2019. In press.
  • Li CH*, Tang X*, Wasnik S, Wang X, Zhang J, Xu Y, Lau KW, Nguyen HB, Baylink DJ. Mechanistic study of the cause of decreased blood 1,25-Dihydroxyvitamin D in sepsis. BMC Infect Dis. 2019. In press.
  • Wasnik S, Baylink DJ, Leavenworth J, Liu C, Bi H, Tang X. Towards Clinical Translation of CD8(+) Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules. Int J Mol Sci. 2019 Sep 28;20(19). pii: E4829. doi: 10.3390/ijms20194829. Review. PubMed PMID: 31569411.
  • Wasnik S, Lakhan R, Baylink DJ, Rundle CH, Xu Y, Zhang J, Qin X, Lau KW, Carreon EE, Tang X. Cyclooxygenase 2 augments osteoblastic but suppresses chondrocytic differentiation of CD90(+) skeletal stem cells in fracture sites. Sci Adv. 2019 Jul 31;5(7):eaaw2108. doi: 10.1126/sciadv.aaw2108. eCollection 2019 Jul. PubMed PMID: 31392271; PubMed Central PMCID: PMC6669009.
  • Xu Y, Cheng Y, Baylink DJ, Wasnik S, Goel G, Huang M, Cao H, Qin X, Lau KW, Chan C, Koch A, Pham LH, Zhang J, Li CH, Wang X, Berumen EC, Smith J, Tang X. In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis.  J Immunol. 2019 May 3. pii: ji1800018. doi: 10.4049/jimmunol.1800018. [Epub ahead of print] PubMed PMID: 31053627.
  • Wasnik S, Rundle CH, Baylink DJ, Yazdi MS, Carreon EE, Xu Y, Qin X, Lau KW, Tang X. 1,25-Dihydroxyvitamin D suppresses M1 macrophages and promotes M2 differentiation at bone injury sites. JCI Insight. 2018 Sep 6;3(17). pii: 98773. doi: 10.1172/jci.insight.98773. [Epub ahead of print] PubMed PMID: 30185660.
  • Choudry M, Tang X, Santorian T, Wasnik S, Xiao J, Xing W, Lau KW, Mohan S, Baylink DJ, Qin X. Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice. Immunology. 2018 Mar 25. doi: 10.1111/imm.12926. [Epub ahead of print] PubMed PMID: 29574762.
  • Xu Y, Wasnik S, Baylink DJ, Berumen EC, Tang X. Overlapping Peptide Library to Map Qa-1 Epitopes in a Protein. J Vis Exp. 2017 Dec 20;(130). doi: 10.3791/56401.PubMed PMID: 29286392.
  • Li CH, Zhang J, Baylink DJ, Wang X, Goparaju NB, Xu Y, Wasnik S, Cheng Y, Berumen EC, Qin X, Lau KW, Tang X. Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis. FASEB J. 2017 Mar 31. pii: fj.201601243R. doi: 10.1096/fj.201601243R. [Epub ahead of print] PubMed PMID: 28363955.
  • Cao H, Xu Y, de Necochea-Campion R, Baylink DJ, Payne KJ, Tang X, Ratanatharathorn C, Ji Y, Mirshahidi S, Chen CS. Application of vitamin D and vitamin D analogs in acute myelogenous leukemia. Exp Hematol. 2017; doi: 10.1016/j.exphem.2017.01.007. PMID: 28174131.
  • Wang X, Zhang J, Baylink DJ, Li CH, Watts DM, Xu Y, Qin X, Walter MH, Tang X. Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis. Sci Rep. 2016 Oct 31;6:36064. doi: 10.1038/srep36064. PubMed PMID: 27796368; PubMed Central PMCID: PMC5086895.
  • Satoorian T, Li B, Tang X, Xiao J, Xing W, Shi W, Lau KW, Baylink DJ, Qin X. MicroRNA223 Promotes Pathogenic T Cell Development and Autoimmune Inflammation in Central Nerve System in Mice. Immunology. 2016 Apr 16. doi: 10.1111/imm.12611. [Epub ahead of print] PubMed PMID: 27083389.
  • Lakhan R, Baylink DJ, William Lau KH, Tang X, Sheng MH, Rundle CH, Qin X. Local administration of AAV-DJ pseudo serotype expressing COX2 provided early onset of transgene expression and promoted bone fracture healing in mice. Gene Ther. 2015 May 12. doi: 10.1038/gt.2015.40. [Epub ahead of print]. PMID: 25965395.
  • Li B, Baylink DJ, Walter MH, Lau KH, Meng X, Wang J, Cherkas A, Tang X, Qin X. Targeted 25 hydroxyvitamin D3 1α-hydroxylase Adoptive Gene Therapy Ameliorates DSS-induced Colitis Without Causing Hypercalcemia in Mice. Mol Ther. 2015; 23(2):339-51. PMID: 25327179.
  • Seong CS, Varela-Ramirez A, Tang X, Anchondo B, Magallanes D, Aguilera RJ. Cloning and characterization of a novel Drosophila stress induced DNase. PLoS One. 2014; 9(8):e103564. PMID: 25083901; PMCID: PMC4118900.
  • Leavenworth JW, Tang X, Kim HJ, Wang X, Cantor H. Amelioration of arthritis through mobilization of peptide-specific CD8+ regulatory T cells. J Clin Invest. 2013; 123(3):1382-9. PMID: 23376792; PMCID: PMC3582146.
  • Xu W, Watts DM, Costanzo MC, Tang X, Venegas LA, Jiao F, Sette A, Sidney J, Sewell AK, Wooldridge L, Makino S, Morrill JC, Peters CJ, Kan-Mitchell J. The nucleocapsid protein of rift valley Fever virus is a potent human CD8(+) T cell antigen and elicits memory responses. PLoS One. 2013; 8(3):e59210. PMID: 23527138; PMCID: PMC3601065.
  • Zhao L, Peng B, Hernandez-Viezcas JA, Rico C, Sun Y, Peralta-Videa JR, Tang X, Niu G, Jin L, Varela-Ramirez A, Zhang JY, Gardea-Torresdey JL. Stress response and tolerance of Zea mays to CeO2 nanoparticles: cross talk among H2O2, heat shock protein, and lipid peroxidation. ACS Nano. 2012; 6(11):9615-22. PMID: 23050848.
  • Fanchiang SS, Cojocaru R, Othman M, Khanna R, Brooks MJ, Smith T, Tang X, Maricic I, Swaroop A, Kumar V. Global expression profiling of peripheral Qa-1-restricted CD8αα+TCRαβ+ regulatory T cells reveals innate-like features: implications for immune-regulatory repertoire. Hum Immunol. 2012; 73(3):214-22. PMID: 21889557; PMCID: PMC3261310.
  • Beeston T, Smith TR, Maricic I, Tang X, Kumar V. Involvement of IFN-γ and perforin, but not Fas/FasL interactions in regulatory T cell-mediated suppression of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2010; 229(1-2):91-7. PMID: 20708278; PMCID: PMC2991517.
  • Kim H-J, Verbinnen B, Tang X, Lu L, Cantor H. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature. 2010; 467(7313):328-32. PMID: 20844537. PMCID: PMC3395240.
  • Smith TRF, Tang X, Maricic I, Garcia Z, Fanchiang S, Kumar V. Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alpha-alpha+TCRalpha-beta+ T cells with regulatory properties. J. Immunol. 2009; 182(11):6959-6968. PMID: 19454693.
  • Tang X. Survival factors from activated accessory cells and their role in triggering autoimmune diseases. Curr Med Chem. 2007; 14(7):797-809. PMID: 17346164.
  • Tang X, Maricic I, Kumar V. Anti-TCR antibody treatment activates a novel population of non-intestinal CD8alpha-alpha+TCRalpha-beta+ regulatory T cells and prevents autoimmune encephalomyelitis. J Immunol. 2007; 178(10):6043-6050. PMID: 17475828.
  • Tang X, Maricic I, Purohit N, Bakamjian B, Reed-Loisel LM, Beeston T, Jensen PE, Kumar V. Regulation of immunity by a novel population of Qa-1-restricted CD8alphaalpha+TCRalphabeta+ T cells. J Immunol. 2006; 177(11):7645-55. PMID: 17114434.
  • Tang X, Smith TRF, Kumar V. Specific control of immunity by regulatory CD8 T cells. Cellular & Molecular Immunology. 2005; 2(1):11-19. PMID: 16212906.
  • Van den Elzen P, Menezes JS, Ametani A, Maverakis E, Madakamutil L, Tang X, Kumar V, Sercarz EE. Limited clonality in autoimmunity: drivers and regulators. Autoimmun Rev. 2004; 3(7-8):524-9. PMID: 15546801.
  • Tang X, Yocum DE, DeJonghe D, Nordensson K. Increased activation-induced cell death in peripheral lymphocytes of rheumatoid arthritis patients: the mechanism of action. Immunology. 2004; 112:496-505. PMCID: PMC1782498.
  • Tang X, Yocum DE, DeJonghe D, Nordensson K. Characterizing a soluble survival signal for activated lymphocytes from CD14+ cells. Immunology. 2002; 107:56-68. PMCID: PMC1782776.