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Faculty


Islam M. Ghazi, BSc Pharm, MSc, PharmD, BCPS, BCACP, BCIDP, FCPP

Associate Professor of Clinical PharmacyClinical Pharmacy SpecialistLab/Clinical Researcher, Scientific Author and Literature Reviewer

BSC & MSC University of Alexandria, EgyptPharmD University of Florida

Description

Dr. Ghazi is a seasoned professional with diverse experience including academia, clinical practice and pharmaceutical industry. He originally earned his Bachelor and Master degree from University of Alexandria, Egypt, then his PharmD from University of Florida. His postgraduate fellowship was completed at the Center of Anti-infective Research and Development, Hartford Hospital, CT.

In addition to teaching in a variety of courses and programs including pharmacology, microbiology, clinical therapeutics, pharmacokinetics and research design, Dr. Ghazi practices in the fields of ambulatory care and infectious diseases. The research interests include investigation of pharmacokinetics and pharmacodynamics of antimicrobials using in vivo animal modeling designed experimentally to simulate various human infections, performing bench-top microbiological testing such as determination of minimum inhibitory concentration, time kill experiments, antibiotic synergy and phenotypic enzyme production, conducting retrospective analysis, case studies, surveillance studies and epidemiological data collection, executing clinical trials with respect to patient screening, protocol implementation, patient follow up and data reporting. In addition, monitoring adhesion to contractual, legal and ethical obligations.

Currently, Dr. Ghazi is board certified in pharmacotherapy, ambulatory care and infectious diseases and a fellow of Philadelphia College of Physicians, also a member of Infectious Diseases Society of America, European Society of Microbiology and infectious Diseases and American College of Clinical Pharmacy.

Specialties

Publications

Journal articles

  • Alrahmany D, Omar AF, Al-Maqbali SRS, Harb G, Ghazi IM. Infections in G6PD-Deficient Hospitalized Patients-Prevalence, Risk Factors, and Related Mortality. Antibiotics (Basel). 2022;11(7):934. DOI: 10.3390/antibiotics11070934
  • Alrahmany D, Omar AF, Alreesi A, Harb G, Ghazi IM. Acinetobacter baumannii Infection-Related Mortality in Hospitalized Patients: Risk Factors and Potential Targets for Clinical and Antimicrobial Stewardship Interventions. Antibiotics (Basel). 2022 Aug 10;11(8):1086. DOI: 10.3390/antibiotics11081086
  • El Nekidy WS, Abdelsalam M, Nusair A, El Lababidi R, Dajani,R, St. John T, Ghazi IM. Is cefoxitin a carbapenem sparing agent in the management of Urinary Tract Infections caused by ESBL producing Enterobacterales? 2022;57(4):568-574. DOI :10.1177%2F00185787211066460
  • El Nekidy WS, Mallat J, Nusair AR, Eshbair AH, Attallah N, Mooty M, Ghosn M, Ghazi IM. Urinary tract infections in hemodialysis patients-The controversy of antimicrobial drug urine concentrations. Hemodial Int. 2022;26(4):548-554. DOI: 10.1111/hdi.13041
  • El Nekidy WS, Mallat J, Nusair AR, Eshbair AH, Attallah N, Mooty M, Ghosn M, Ghazi IM. Urinary tract infections in hemodialysis patients-The controversy of antimicrobial drug urine concentrations. Hemodial Int. 2022. DOI: 10.1111/hdi.13041
  • Alrahmany D, Omar AF, Al-Maqbali SRS, Harb G, Ghazi IM. Infections in G6PD-Deficient Hospitalized Patients-Prevalence, Risk Factors, and Related Mortality. Antibiotics (Basel). 2022 Jul 12;11(7):934. DOI: 10.3390/antibiotics11070934
  • El Nekidy WS, Cha R, Ghazi IM. Practical considerations for vancomycin dosing in hemodialysis patients; perspectives from the nephrology stewardship pharmacist. Clinical Nephrology. 2022 DOI: 10.5414/CN110664
  • Alrahmany D, Omar AF, Alreesi A, Harb G, Ghazi IM. Acinetobacter baumannii Infection-Related Mortality in Hospitalized Patients: Risk Factors and Potential Targets for Clinical and Antimicrobial Stewardship Interventions. Antibiotics (Basel). 2022 Aug 10;11(8):1086 DOI: 10.3390/antibiotics11081086
  • El Nekidy W, Abdelsalam M, Nusair A, El Lababidi R, Dajani,R, St. John T, Ghazi IM. Is cefoxitin a carbapenem sparing agent in the management of Urinary Tract Infections caused by ESBL producing Enterobacterales?. Hospital Pharmacy. 2022 DOI :10.1177%2F00185787211066460
  • Alrahmany D, Ereshefsky BJ, El Nekidy WS, Harb G, Pontiggia L, Ghazi IM. Risk Factors for Recurrence of Clostridioides difficile in Hospitalized Patients. J Infect Public Health. 2021;14(11):1642-1649. DOI: 10.1016/j.jiph.2021.09.016
  • Alrahmany D, Omar AF, Harb G, El Nekidy WS, Ghazi IM. Acinetobacter baumannii Infections in Hospitalized Patients, Treatment Outcomes. Antibiotics (Basel). 2021;10(6). DOI: 10.3390/antibiotics10060630
  • Alrahmany D, Ghazi IM. Cytokine storm is the cryptic killer behind coronavirus disease-2019 infections, review of the current evidence to identify therapeutic options. Reviews in Medical Microbiology. 2021;32(1):57-65. DOI: 10.1097/MRM.0000000000000242
  • El Nekidy WS, Elrefaei H, St. John TJL, et al. Ertapenem Neurotoxicity in Hemodialysis Patients—Safe and Effective Dosing Is Still Needed: A Retrospective Study and Literature Review. Annals of Pharmacotherapy. 2021;55(1):52-58. DOI:10.1177/1060028020938059
  • Ereshefsky BJ, Alrahmany D, El Nekidy WS, Pontiggia L, Ghazi IM. Optimal vancomycin dose in the treatment of Clostridium difficile infection, antimicrobial stewardship initiative. J Chemother. 2021 May;33(3):165-173. DOI: 10.1080/1120009X.2020.1790166
  • Ghazi IM, El Nekidy WS, Asay R, Fimognari P, Knarr A, Awad M. Simultaneous administration of imipenem/cilastatin/relebactam with selected intravenous antimicrobials, a stewardship approach. PLoS One. 2020 May 18;15(5):e0233335. DOI: 10.1371/journal.pone.0233335
  • El Nekidy WS, Kadri A, Lee-St John TJ, Ghazi IM, Soong DC. Role of nephrology pharmacists in the management of anemia in outpatient dialysis units: A Canadian model. Clin Nephrol. 2020 Jul;94(1):36-42. DOI: 10.5414/CN110066
  • Ghazi IM Dr, El Nekidy WS Dr, Sood A Mr, Dulku A Ms, Patel R Ms, Patel K Ms, Li P Ms. Y-site Administration of Imipenem/Cilastatin/Relebactam With Common Intravenous Medications. Clin Ther. 2020 Mar;42(3):475-485. DOI: 10.1016/j.clinthera.2020.01.017
  • El Nekidy, Wasim S et al. “Treatment of recurrent urinary tract infections in anuric hemodialysis patient, do we really need antimicrobial urinary concentration?.” IDCases vol. 20 e00748. 21 Mar. 2020. DOI: 10.1016/j.idcr.2020.e00748
  • El Nekidy WS, El-Masri MM, Ghazi IM, Soong D. Factors predicting vancomycin therapy outcomes in hemodialysis outpatients and the role of the nephrology stewardship pharmacist. Hemodial Int. 2019 Oct;23(4):449-457. DOI: 10.1111/hdi.12775
  • Alrahmany D, Albeloushi A, Alreesi I, Alzaabi A, Alreesi M, Pontiggia L, Ghazi IM. Exploring bacterial resistance in Northern Oman, a foundation for implementing evidence-based antimicrobial stewardship program. Int J Infect Dis. 2019;83:77-82. DOI : 10.1016/j.ijid.2019.04.004
  • El Nekidy WS, Soong D, Kadri A, Tabbara O, Ibrahim A, Ghazi IM. Salvage of Hemodialysis Catheter in Staphylococcal Bacteremia: Case Series, Revisiting the Literature, and the Role of the Pharmacist. Case Reports in Nephrology and Dialysis. 2018;8(2):121-129. DOI : 10.1159/000489923
  • Ghazi IM, Monogue ML, Tsuji M, Nicolau DP. Humanized Exposures of Cefiderocol, a Siderophore Cephalosporin, Display Sustained in vivo Activity against Siderophore-Resistant Pseudomonas aeruginosa. Pharmacology. 2018;101(5-6):278-284.  DOI: 10.1159/000487441
  • Ghazi IM, Monogue ML, Tsuji M, Nicolau DP. Pharmacodynamics of cefiderocol, a novel siderophore cephalosporin, in a Pseudomonas aeruginosa neutropenic murine thigh model. Int J Antimicrob Agents. 2018 Feb;51(2):206-212.  DOI: 10.1016/j.ijantimicag.2017.10.008
  • Ghazi IM, Grupper M, Nicolau DP. Antibacterial activity of human simulated epithelial lining fluid concentrations of amikacin inhale alone and in combination with meropenem against Acinetobacter baumannii. Infect Dis (Lond). 2017 Nov-Dec;49(11-12):831-839.  DOI: 10.1080/23744235.2017.1356933
  • El Nekidy, Wasim S et al. “Successful treatment of multidrug resistant Klebsiella pneumoniae using dual carbapenem regimen in immunocompromised patient.” IDCases vol. 9 53-55. 15 Jun. 2017. DOI: 10.1016/j.idcr.2017.06.005
  • Ghazi, I.M., Grupper, M. & Nicolau, D.P. Anti-staphylococcal activity resulting from epithelial lining fluid (ELF) concentrations of amikacin inhale administered via the pulmonary drug delivery system. Ann Clin Microbiol Antimicrob 16, 2 (2017). DOI: 10.1186/s12941-017-0178-0
  • Ghazi I, Hamada Y, Nicolau DP. Physical compatibility of tedizolid phosphate with selected i.v. drugs during simulated Y-site administration. Am J Health Syst Pharm. 2016 Nov 1;73(21):1769-1776. DOI: 10.2146/ajhp150721
  • Kuti JL, Ghazi IM, Quintiliani R Jr, Shore E, Nicolau DP. Treatment of multidrug-resistant Pseudomonas aeruginosa with ceftolozane/tazobactam in a critically ill patient receiving continuous venovenous haemodiafiltration. Int J Antimicrob Agents. 2016 Sep;48(3):342-3. DOI: 10.1016/j.ijantimicag.2016.06.005
  • Ghazi IM, Crandon JL, Lesho EP, McGann P, Nicolau DP. In vivo efficacy of humanized high dose meropenem and comparators against Pseudomonas aeruginosa isolates producing verona integron-encoded metallo-β-lactamase (VIM). Heliyon. 2016;2(6):e00121. Published 2016 Jun 16.  DOI: 10.1016/j.heliyon.2016.e00121
  • Ghazi IM, Nicolau DP, Nailor MD, Aslanzadeh J, Ross JW, Kuti JL. Antibiotic Utilization and Opportunities for Stewardship Among Hospitalized Patients With Influenza Respiratory Tract Infection. Infect Control Hosp Epidemiol. 2016 May;37(5):583-9. DOI: 10.1017/ice.2016.17
  • Ghazi IM, Crandon JL, Lesho EP, McGann P, Nicolau DP. Efficacy of humanized high-dose meropenem, cefepime, and levofloxacin against Enterobacteriaceae isolates producing Verona integron-encoded metallo-β-lactamase (VIM) in a murine thigh infection model. Antimicrob Agents Chemother. 2015;59(11):7145-7147.  DOI: 10.1128/AAC.00794-15

Books

  • Evolving Rapid Diagnostics Tools, Diaa Alrahmany, Ghazi I.M - Frontiers in Anti-infective Agents 2020-11 | 21st Century Challenges in Antimicrobial Therapy and Stewardship, Bentham Science. DOI: 10.2174/9789811461835120030009
  • Molecular Basis of Resistance II (Gram-negative resistance), Diaa Alrahmany, Ghazi I.M - Frontiers in Anti-infective Agents 2020-11, 21st Century Challenges in Antimicrobial Therapy and Stewardship, Bentham Science.  DOI: 10.2174/9789811461835120030007
  • Molecular Basis of Resistance III (Antifungal resistance), Ghazi I.M., Diaa Alrahmany, Wasim El Nekeidy. Frontiers in Anti-infective Agents, 2020-11, 21st Century Challenges in Antimicrobial Therapy and Stewardship, Bentham Science, Singapore. DOI: 10.2174/9789811461835120030008
  • Principles of Pharmacokinetics. Ghazi I.M., Cawley M. In “Remington the Science and Practice of Pharmacy” Philadelphia College of Pharmacy, Elsevier USA 2020. DOI: 10.1016/C2018-0-04991-9
  • Ambulatory care for hemodialysis patients. In Ambulatory Care Self-Assessment Program (ACSAP). El Nekidy WS, Ghazi IG. American College of Clinical Pharmacy (ACCP) 2018.
  • Principles of pharmacokinetic/pharmacodynamic optimization for antibiotic dosing. In Antibiotic stewardship: principles and practice. Ghazi I.M., Kuti J.L., Nicolau D.P. CABI international, London, UK. 2017 ISBN 9781315152110 (e-book)
  • Complementary and alternative options to antimicrobial chemotherapy. Ghazi IM Alrahmany D, in Antimicrobial Stewardship, practical perspectives Bentham Science.

Lectures and Presentations

International Conference Participation

  • Comparative efficacy of ceftazidime/avibactam and ceftolozane/tazobactam against multidrug-resistant Pseudomonas aeruginosa in patients on renal replacement therapy. 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2023, Copenhagen, Denmark
  • Infections in G6PD deficient patients, predictors for infection-related mortalities and treatment outcomes. 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2023, Copenhagen, Denmark
  • Clinical outcomes of Candida auris management: a retrospective study. 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2023, Copenhagen, Denmark
  • Stability of Imipenem/Cilastatin/Relebactam under different temperature and administration conditions. IDWeek, Infectious Diseases Society of America, 2022, Washington DC, District of Columbia, USA
  • El Nekidy WS, Abdelsalam M, Nusair A, El Lababidi R, Ghazi IM. Clinical outcomes of Ceftolozane/Tazobactam in infected patients utilizing renal replacement therapies, a case series observational study. American College of Clinical Pharmacy. ACCP global conference, Oct 15-18, 2022, San Francisco, CA, USA
  • El Nekidy WS, Dajani R, Ghazi IM. Urinary tract infections in Hemodialysis patients - The controversy of antimicrobial urine concentrations.  American College of Clinical Pharmacy. ACCP global conference, Oct 15-18, 2022, San Francisco, CA, USA
  • El Nekidy WS, Mallat J, Nusair AR, Ghazi IM. Microbiologic outcomes of Ceftazidime/Avibactam in patients with bacteremia or pneumonia utilizing renal replacement therapies, a retrospective cohort study. American College of Clinical Pharmacy. ACCP global conference, Oct 15-18, 2022, San Francisco, CA, USA
  • Ghazi IM, Alrahmany D, Harb G, Nicolau D. Stability of Imipenem/Cilastatin/Relebactam under different temperature and administration conditions. IDWeek, Infectious Diseases Society of America, Oct 19-23, 2022, Washington DC, District of Columbia, USA
  • Resistance determinants in cefiderocol resistant E. Coli. 32nd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2022, Lisbon, Portugal
  • Acinetobacter baumannii Infections in Hospitalized Patients, Treatment Outcomes, 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), 2021, Viena, Austria
  • Biofilm formation in cefiderocol-resistant Acinetobacter baumannii. 31st European Congress of Clinical Microbiology and Infectious Diseases ECCMID 2021.
  • Exploring Bacterial Resistance in Northern Oman, a Stewardship Initiative to Improve Antibiotic Prescription, Open Forum Infectious Diseases, 2018-11. Infectious Diseases Society of America, ID-Week 2018, San Francesco, CA, USA (DOI: 10.1093/ofid/ofy210.1434)
  • Cluster cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Oman, Clinical Case Report, International congress of infectious diseases (ICID-2020) Kuala-Lumpur, Malaysia.
  • Risk factors associated with the mortality of Acinetobacter baumannii, Access Microbiology, 2020-07-01 (DOI: 10.1099/acmi.ac2020.po0353)
  • Clostridium difficile infection risk of recurrence and candidates for preventive therapy, a stewardship approach, International Journal of Infectious Diseases, 2020, (ICID-2020) Kuala-Lumpur, Malaysia. (DOI: 10.1016/j.ijid.2020.09.971)
  • Multi-drug resistant Acinetobacter baumannii infection, risk factors for mortality, International Journal of Infectious Diseases, 2020, (ICID-2020) Kuala-Lumpur, Malaysia. DOI: 10.1016/j.ijid.2020.09.428
  • Efficacy of the recommended ceftazidime/avibactam dose in treating CRE Enterobacteriaceae in critically ill patients utilizing renal replacement therapies. Kidney Week 2020, USA
  • Outcomes of Ceftolozane/Tazobactam recommended dose in treating multi-drug resistance bacteria in critically ill patient utilizing renal replacement therapy. Kidney Week 2020, USA
  • Treatment of urinary tract infections in haemodialysis patients: the controversy about antimicrobial urine concentration. European Congress on Clinical Microbiology and Infectious Diseases ECCMID 2020, Paris, France
  • Extended spectrum beta-lactamase producing Enterobacteriaceae urinary tract infections: is cefoxitin an effective therapy? European Congress on Clinical Microbiology and Infectious Diseases ECCMID 2020, Paris, France
  • Role of nephrology pharmacists in the management of anemia in outpatient dialysis units - A Canadian Model. Kidney Week, American Society of Nephrology, Washington DC, USA Nov 2019
  • Factors predicting ertapenem induced neurotoxicity in hemodialysis patients. Kidney Week, American Society of Nephrology, Washington DC, USA Nov 2019
  • Extrinsic Assessments in a Competency-Driven Curriculum: Implementation and Impact on Student Confidence. American Association of Colleges of Pharmacy Annual Meeting. Chicago, IL, USA July 2019
  • A Multimodal Real-Time Assessment Process and Its Impact on Student Achievement and Progression in the First Year of a Doctor of Pharmacy Program. American Association of Colleges of Pharmacy Annual Meeting. Chicago, IL, USA July 2019
  • Implementation and Impact of Extrinsic Assessments in a Competency-Driven Curriculum. Bright Idea Poster Session. University of the Sciences. May 2019
  • Simultaneous administration of imipenem/cilastatin/relebactam with intravenous drugs, a stewardship approach. European Congress on Clinical Microbiology and Infectious Diseases ECCMID 2019, Amsterdam, Netherlands
  • Outcomes of vancomycin guidelines-recommended dosing in outpatients undergoing hemodialysis, a retrospective analysis. European Congress on Clinical Microbiology and Infectious Diseases ECCMID 2017, Vienna, Austria
  • Activity of S-649266 siderophore conjugated cephalosporin and comparators against Pseudomonas aeruginosa in murine thigh infection model. ASM Microbe 2016, Boston, MA, USA
  • Anti-staphylococcal Activity Resulting from Achievable Epithelial Lining Fluid (ELF) Concentrations of Amikacin Inhalation Administered via the Pulmonary Drug Delivery System. ASM Microbe 2016, Boston, MA, USA
  • Antibacterial activity of human simulated epithelial lining fluid concentrations of Amikacin Inhale alone and in combination with meropenem against Acinetobacter baumannii. European Congress on Clinical Microbiology and Infectious Diseases ECCMID 2016, Amsterdam, Netherlands
  • Compatibility of Tedizolid Phosphate with select intravenous drugs during simulated Y-site conditions. American Society of Health-System Pharmacy midyear meeting 2015, New Orleans, LA, USA
  • Efficacy of meropenem and comparators against Pseudomonas aeruginosa producing VIM. Interscience Conference for Antimicrobial Agents and Chemotherapy ICAAC/ICC 2015, San Diego, CA, USA
  • In vivo efficacy of carbapenems against Enterobacteriaceae isolates producing MBL, VIM. Interscience Conference for Antimicrobial Agents and Chemotherapy ICAAC/ICC 2015, San Diego, CA, USA

Exhibits

Editorial experience

Section editor of “Pharmacokinetics/Pharmacodynamics” in the book “Remington the Science and Practice of Pharmacy” Philadelphia College of Pharmacy, Elsevier, USA 2020 eBook ISBN: 9780128223895

Editor of the book 21st Century Challenges in Antimicrobial Therapy and Stewardship, in book series, Frontiers in Anti-infective Agents 2020-11| 21st Century Challenges in Antimicrobial Therapy and Stewardship, Bentham Science. DOI: 10.2174/97898114618351200301

Editor of special issue; Advances in Antimicrobial Therapy and Combating Resistance, in Frontiers in Pharmacology”

Editor of special issue; Antibiotics Use and Stewardship in Hospitals and Outpatients Care Facilities, in “Antibiotics”

Editor of special issue; Antibiotic-Resistance, Determinants, Prevention, Clinical Implications and Stewardship, in “Antibiotics”

Editor of the book. Antimicrobial Stewardship, practical perspectives Bentham Science

Honors/Awards

• Fellowship of College of Physicians of Philadelphia, Philadelphia, USA (2020)
• Distinguished Investigator Award, American College of Clinical Pharmacy, (Infectious Diseases Professional Network) USA. (2020)
• Dean’s award for Excellence in Research and Scholarly Activity, Philadelphia College of Pharmacy at University of the Sciences. (2019)
• Research Day best poster presentation, Philadelphia College of Pharmacy at University of the Sciences. (2019)
• Assessment team honorable mention, American Association of College of Pharmacy. (2019)
• Fellowship travel award, American Society of Microbiology, International Conference on Antimicrobial Agents and Chemotherapy, USA. (2015)

Memberships


  • Infectious Diseases Society of America (IDSA) Arlington, VA, USA
  • American Society of Health-System Pharmacists (ASHP) Bethesda, MD, USA
  • American College of Clinical Pharmacy (ACCP) Lenexa, KS, USA
  • European Society of Clinical Microbiology and Infectious Diseases, Geneva, Switzerland
  • American Society of Microbiology (ASM) Washington, D.C., USA
  • Society of Infectious Diseases Pharmacists (SIDP) Fairfield, CT, USA
  • Canadian Pharmacist Association (CPhA) Ottawa, ON, Canada