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Faculty

Rutesh H. Dave

Professor of Pharmaceutical Sciences

Ph.D., Long Island University, Brooklyn, NYB.S. Pharm, K.L.E. College of Pharmacy, Belgaum, India

Description

Dr. Dave joined Long Island University in 2008, before joining the college, Dr. Dave worked at Par pharmaceuticals and SigmaPharm as a senior scientist and group leader of R&D formulation and worked on various solid dosage form development from laboratory to scale-up. Dr. Dave started his laboratory at LIU with a dissolution apparatus and UV spectrophotometer and few chemicals. He started his laboratory with few master students and developed many joint projects with pharmaceutical industries and converted his laboratory into a full-fledged research laboratory. He also served as both faculty program advisor (Industrial Pharmacy and Pharmaceutical Sciences) and Division Director. Dr. Dave was also instrumental in opening the LIU-Natoli institute for Industrial Pharmacy Research and Development where scientists from academia, industry and governmental agencies can work to develop and solve problems related with solid dosage form. Dr. Dave also serves as a principal investigator of that institute. Dr. Dave is also the recipient of Newton award for his excellence in teaching and is also a recipient of the Founders award for his service to the college. Dr. Dave’s students have received various research awards at regional and national level. Dr. Dave has published extensively in national and international journals and is also reviewer and editorial boards of several scientific journals. His laboratory is divided into four research areas:

  • Solubility enhancement using innovative approaches
  • Powder characterization
  • Generic and 505 (b) 2 development
  • Developing oral strip formulation

Specialties

Pre-formulation, formulation, drug delivery systems, solid dispersion, quick dissolving strips, Quality based design, powder characterization and rheology manufacturing and scale-up operations, nanoparticle based systems and roller compaction

Publications

  • Rathod, VR, Shah, DA and Dave, RH, Systematic implementation of quality by design (QBD) to develop NSAID loaded nanostructured lipid carriers for ocular application: preformulation screening studies and statistical hybrid design for optimization of variables, Drug development and industrial pharmacy, Vol 46 (3), 443-455, 2020
  • Xu, X, Coskunturk, Y, Dave, VS, Kuriyilel, JV, Wright, MF, Dave, RH, Cetinkaya, C, Effects of comnpaction pressure, speed and punch head profile on the ultrasonically extracted physical properties of pharmaceutical compacts, International journal of Pharmaceutics, Vol 575, 118993, 2020
  • Gajera, BY, Shah, DA, Dave, RH. Development of an amorphous nanosuspension by sonoprecipitation-formulation and process optimization using design of experiment methodology. International journal of Pharmaceutics, Vol 559, 348-359, 2019
  • Shah, HS, Rubin, RF, Lakhwani, GR, DiGregorio, R and Dave, RH. Stability of insulin determir injection in different primary packaging systems at room temperature, Journal of Pharmacy Practice. https://doi.org/10.1177/0897190019867852, 2019
  • Xu, T., Nahar J, Dave R, Bates and Morris, K, Polymorphic transformation of Indomethacin during hot melt extrusion granulation: Process and dissolution control, Pharm Res, Vol 35 (7), p.140, 2018
  • Chaturvedi k, Gajera BY, Xu T, Shah H and R. H. Dave, Influence of processing methods on physico-mechanical properties of ibuprofen/HPC-SSL formulation, Pharm Dev Technol, 2018
  • Dudhat, S.M., C.N. Kettler, and R.H. Dave, To Study Capping or Lamination Tendency of Tablets Through Evaluation of Powder Rheological Properties and Tablet Mechanical Properties of Directly Compressible Blends. AAPS PharmSciTech, Vol 18 (4), p.1177-1189, 2017
  • Dugar, R.P., B.Y. Gajera, and R.H. Dave, Fusion Method for Solubility and Dissolution Rate Enhancement of Ibuprofen Using Block Copolymer Poloxamer 407. AAPS PharmSciTech, Vol 17 (6), p. 1428-1440, 2016
  • Dugar, R.P., P. Gupta, and R.H. Dave, Effect of relative humidity on acetaminophen tablet properties prepared by different techniques using polyvinylpyrrolidine derivatives as binder. International Journal of Pharmaceutical Sciences and Research, Vol. 6 (11), pg. 4629-4638, 2015.
  • Jagia, M., M. Trivedi, and R.H. Dave, To Evaluate the Effect of Solvents and Different Relative Humidity Conditions on Thermal and Rheological Properties of Microcrystalline Cellulose 101 Using METHOCEL™ E15LV as a Binder. AAPS PharmSciTech, Vol.14 (4), pg. 995-1006, 2016
  • Shah, D.A., S.B. Murdande, and R.H. Dave, A Review: Pharmaceutical and Pharmacokinetic Aspect of Nanocrystalline Suspensions. Journal of Pharmaceutical Sciences, Vol. 105 (1), pg. 10-24, 2016
  • Patel, A.A. and R.H. Dave, Development and characterization of innovative liquid salt based formulations of sparingly soluble drugs. International Journal of Pharmaceutical Sciences and Research, Vol. 6 (6), p. 2316-2327, 2015
  • Al-Nemrawi, N.K. and R.H. Dave, Effect of Formulation Variables on Poly (lactic-co-glycolic acid) Nanoparticle Properties: A Factorial Design Study. Journal of Pharmaceutical Sciences and Pharmacology, 2015. 2(1): p. 1-10.
  • Murdande, S.B., D.A. Shah, and R.H. Dave, Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals. Journal of pharmaceutical sciences, 2015. 104(6): p. 2094-2102.
  • Dugar, R.P. and R.H. Dave, To study the effects of solvent and relative humidity on rheological and thermal properties of microcrystalline cellulose granules using hydroxypropyl methylcellulose as binder. International Journal of Pharmaceutical Sciences and Research, 2014. 5(9): p. 3616.
  • Al-Nemrawi, N.K. and R.H. Dave, Formulation and characterization of acetaminophen nanoparticles in orally disintegrating films. Drug delivery, 2016. 23(2): p. 540-549.
  • Chaudhari, S.P. and R.H. Dave, To prepare and characterize microcrystalline cellulose granules using water and isopropyl alcohol as granulating agents and determine its end-point by thermal and rheological tools. Drug development and industrial pharmacy, 2014(0): p. 1-9.
  • Dave, R.H., D.A. Shah, and P.G. Patel, Development and evaluation of high loading oral dissolving film of aspirin and acetaminophen. Journal of Pharmaceutical Sciences and Pharmacology, 2014. 1(2): p. 112-122.
  • Patel, A.D., A. Agrawal, and R.H. Dave, Investigation of the effects of process variables on derived properties of spray dried solid-dispersions using polymer based response surface model and ensemble artificial neural network models. European Journal of Pharmaceutics and Biopharmaceutics, 2014. 86(3): p. 404-417.
  • Trivedi, M.R. and R.H. Dave, To study physical compatibility between dibasic calcium phosphate and cohesive actives using powder rheometer and thermal methods. Drug development and industrial pharmacy, 2014. 40(12): p. 1585-1596.
  • Patel, A.D., A. Agrawal, and R.H. Dave, Development of polyvinylpyrrolidone‐based spray‐dried solid dispersions using response surface model and ensemble artificial neural network. Journal of pharmaceutical sciences, 2013. 102(6): p. 1847- 1858.
  • Patel, V.I. and R.H. Dave, Evaluation of colloidal solid dispersions: physiochemical considerations and in vitro release profile. AAPS PharmSciTech, 2013. 14(2): p. 620-628.
  • Okoye, P., S.H. Wu, and R.H. Dave, To evaluate the effect of various magnesium stearate polymorphs using powder rheology and thermal analysis. Drug development and industrial pharmacy, 2012. 38(12): p. 1470-1478.
  • Dave, R.H., S.H. Wu, and L.D. Contractor, To determine the end point of wet granulation by measuring powder energies and thermal properties. Drug development and industrial pharmacy, 2012. 38(4): p. 439-446.
  • Dave, R.H., et al., To evaluate the effect of addition of an anionic surfactant on solid dispersion using model drug indomethacin. Drug development and industrial pharmacy, 2012. 38(8): p. 930-939.
  • Matharu, A.S., et al., Evaluation of hydroxypropyl methylcellulose matrix systems as swellable gastro‐retentive drug delivery systems (GRDDS). Journal of pharmaceutical sciences, 2011. 100(1): p. 150-163.
  • Wu, Z., et al., Development of acetaminophen proline prodrug. Bioorganic & medicinal chemistry letters, 2010. 20(13): p. 3851-3854.

Lectures and Presentations

  • Shah, Jaimin, Modi, Nisarg, Patel, Kinjalben, Patel, Sarsvatkumar, Dave, Rutesh “Assessing the Permeability of a Potent Antipsychotic Drug (Risperidone) through Human Cadaver Skin: Effect of Permeability Enhancers and Formulation Variables. AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Attluri, Hari, “Determination of Wet Granulation End-point for Microcrystalline Cellulose (MCC, Avicel® PH 200) Prepared using Two Different Grades of Binder Polyvinylpyrrolidone (Kollidon®90F and Kollidon®30) using Thermal and Powder Rheological Analysis”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Patel, Hardik, Ren, Chen, Maniar, Manoj, “Effect of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin on Solubility and Aqueous Stability of Rigosertib&[reg]: A Novel Anticancer Drug”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Parikh, Harshil, Patel, Ashwinkumar, “Effect of Preparation Methods and Feed Concentrations on Derived Properties of Carbamazepine (CBZ) Binary Solid Dispersions (SD)”, AAPS Annual Meeting, San Antonio 2013.
  • Murdanade, Sharad, Shah, Dhaval, Dave, Rutesh, Patel, Jigna, Shanker, Ravi, “Investigation of Crystalline Nanoparticles: Thermodynamic and Kinetic Properties”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Patel, Anant, “Liquid Salt as Green Solvent: A Novel Eco-friendly Technique to Enhance Solubility and Stability of Poorly Soluble Drugs”, AAPS Annual Meeting, San Antonio 2013.
  • Dugar, Rohit, Jagia, Moksh, Dave, Rutesh, “A Study to Compare the Effect of Solvents on Thermal and Rheological Properties of Granules of Microcrystalline Cellulose (Avicel® PH 101) Using Hydroxypropyl Methylcellulose (MethocelTM E5 and E15 Premium LV) as Binder on Exposure to Different Relative Humidity (RH) Conditions”, AAPS Annual Meeting, San Antonio 2013.
  • Jagia, Moksh, Dave, Rutesh, “A Study to Determine the Optimum Wet Granulation End Point and Evaluate the Fundamental Rheological and Thermal Properties of Microcrystalline Cellulose (Avicel® PH 101 ) Using Hydroxypropyl Methylcellulose (MethocelTM E15 Premium LV ) as Binder with Different Solvents”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Karan, Kapish, Tank, Dharti, “To Characterize and Evaluate Avicel PH 105 Granules Prepared Using Two Grades of High Viscosity Binder Methocel K100M CR and Methocel K4M CR and Characterize Them Using Rheological and Thermal Effusivity Techniques”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Jassu, Antara, “To Determine the End-point of Wet Granulation and Evaluate Microcrystalline Cellulose (MCC, Avicel PH 200) Granules Prepared Using Polyvinylpyrrolidone (Kollidon 25) as a Binder and Study Their Rheological and Thermal Properties”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Dugar, Rohit, “To Determine the Optimum Wet Granulation End Point and Study the Fundamental Rheological and Thermal Properties of Microcrystalline Cellulose (Avicel® PH 101) Using Hydroxypropyl Methylcellulose (MethocelTM E5 Premium LV) as a Binder with Different Solvents”, AAPS Annual Meeting, San Antonio 2013.
  • Talekar, Sawani, Dave, Rutesh, “To Evaluate and Determine the End-Point of Cellactose® 80 (α-lactose Monohydrate and Microcrystalline Cellulose) Wet Granulation Using Water by Thermal and Rheological Techniques”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Parikh, Kuntal, “To Evaluate the Effect of Cationic Surfactant on Dissolution Behavior of Solid Dispersion of Poorly Soluble Drug Using Indomethacin as a Model Drug”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Dudhat, Siddhi, “To Evaluate Wet Granulated Tablet Properties through the Unified Compaction Curve Using Microcrystalline Cellulose (MCC, Avicel&[reg] 101 and 200)”, AAPS Annual Meeting, San Antonio 2013.
  • Chaudhari, Smruti, Dave, Rutesh, “To Study the Effect of Different Molecular Weight Polymers (Polyvinylpyrollidone (PVP, Plasdone) and Hydroxypropyl Methyl Cellulose (HPMC, Methocel)) as a Potential Antiprecipitating (AP) Agents on Supersaturation”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Patel, Ashwinkumar, Agrawal, Anjali, “To Understand and Optimize the Spray-Dried Solid Dispersions (SSDs) Process Using Polymer Based Response Surface Model (RSM) and Ensemble Artificial Neural Network (EANN) Models: A Potential Approach for the Development of the SSDs”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Patel, Ashwinkumar, Agrawal, Anjali, “To Understand and Optimize the Spray-Dried Solid Dispersions (SSDs) Process Using Polymer Based Response Surface Model (RSM) and Ensemble Artificial Neural Network (EANN) Models: Effect of Different Solvents and Atomization Parameters”, AAPS Annual Meeting, San Antonio 2013.
  • Dave, Rutesh, Patel, Ashwinkumar, Agrawal, Anjali, “Understand and Optimize the Spray-Dried Solid Dispersions (SSDs) Process Using Polymer Based Response Surface Model (RSM) and Ensemble Artificial Neural Network (EANN) Models: Effect of Feed Concentration and Drug Loading”, AAPS Annual Meeting, San Antonio 2013.
  • H. Patel, C. Ren, M. Maniar, D. Taft, R. Dave, “Determination of degradation Kinetics of Estybon- A novel Anticancer Drug in Acidic Conditions”, AAPS Annual Meeting, Chicago, 2012.
  • H. Patel, D. Shah, C. Rhen, M. Maniar, D. Taft, R. Dave, “To Study Effects of an Anion Exchange Resin on Dissolution of Estybon: A novel Anticancer Drug”, AAPS Annual Meeting, Chicago, 2012.
  • H. Nie, R. Dave, “To Determine and Differentiate the End-point of Wet Granulation for various Grades of HPMC Utilizing Thermal and Rheological approaches”, AAPS Annual Meeting, Chicago, 2012.
  • A. Patel, R. Dave, “To investigate solvent effects on physicochemical and dissolution properties of spray dried ibuprofen and its sodium salt”, AAPS Annual Meeting, Chicago, 2012.
  • M. Trivedi, R. Dave, “A study of Evaluate the effect of acetaminophen on various stages of wet granulation using Pharmaceutical hydrates”, AAPS Annual Meeting, Chicago, 2012.
  • Haichen Nie and Rutesh H. Dave: “To determine differences between two grades of Hydroxypropyl
  • Methylcellulose using powder rheometer and thermal effusivity” (Poster). Northeast Regional Discussion Group 2011 Summer Conference, Friday (September 2, 2011), Boston.
  • Dhaval Shah and Rutesh H. Dave: “ To develop and evaluate orally disintegrating film (ODF) with high
  • loading dose” (Podium presentation). Northeast Regional Discussion Group 2011 Summer Conference, Friday (September 2, 2011), Boston.
  • M. Trivedi and R. Dave: “An approach to predetermine powder characteristics as compared with conventional measurements”. Presented at 2011 AAPS annual meeting.
  •  Nie, M. Trivedi and R. Dave: “ To determine the difference in energies associated with powder flowability using various grades of hydroxypropyl methylcellulose” Presented at 2011 AAPS annual meeting.
  • A.M. Virani, P.B. Shah, S. Wu, J. Yin, A. Harris and R.H. Dave: “ To evaluate thermal and rheological properties of EMDEX using Stear-o-Wet and magnesium stearate monohydrate”. Presented at 2010 AAPS annual meeting.
  • D.A. Shah and R.H. Dave: “ To develop and evaluate orally disintegrating film (ODF) of Aspirin”. Presented at 2010 AAPS annual meeting.
  • P.P. Jariwala and R.H. Dave: “ To analyze the formation of wet and dry granules and it’s properties using water and binder (PVP k 29/32) solution on microcrystalline cellulose (MCC 105)”. Presented at 2010 AAPS annual meeting.
  • M.R. Trivedi and R.H. Dave: “ To determine the rheological and thermal effects of cohesive active on pharmaceutical hydrates”. Presented at 2010 AAPS annual meeting.
  • S.P. Chaudhari and R.H. Dave: “ To determine the fundamental rheological and thermal properties of microcrystalline cellulose (MCC 102) with water and alcohol as wet granulating agents”. Presented at 2010 AAPS annual meeting.
  • A.S. Matharu, A.P. Simonelli, M. Motto, M.R. Patel and R.H. Dave: “Characterization of gastro-retentive drug delivery systems (GDDS) using swellable polymers”. Presented at 2009 AAPS annual meeting.
  • A.Oskoui, P. Okoye, R. Dave, S.H. Wu: “Determination of powder flow properties of acetaminophen blends lubricated with magnesium stearate of various polymorph ratios”. Presented at 2009 AAPS annual meeting.
  • H.H. Patel, S.Wu, R. Pugh, T. Freeman, B. Armstrong and R.H. Dave: “Determining endpoint for wet granulation using rheological and effusivity measurements”. Presented at 2009 AAPS annual meeting.
  • A.D. Patel, V.I. Patel, P.S. Aremanda, L.D. Contractor and R.H. Dave: “Enhancement of solubility of poorly water soluble drugs by incorporating porous materials in solid dispersion”. Presented at 2009 AAPS annual meeting.
  • P.Okoye, S. Wu, J. Yin, R. Pugh, T. Freeman and R.H. Dave: “To measure the additive effect of magnesium stearate and Stear-O-Wet on wet granulation”. Presented at 2009 AAPS annual meeting.
  • P.G. Patel and R.H. Dave: “To develop and evaluate oral dissolving film (ODT) containing high dose of acetaminophen”. Presented at 2009 AAPS annual meeting
  • H.H.Patel, A.D.Patel, A.S. Patel and R.H. Dave: “ To evaluate the effect o incorporation of surfactant on physical mixtures and solid dispersion” Presented at AAPS annual meeting 2008.
  • P.Okoye, A. Harris, M.Kelly, S.H.Wu and R.H. Dave: “Evaluation and characterization of new lubricant system” Presented at AAPS annual meeting 2008.
  • T.Mahnaj, F. Plakogiannis, S.Ahmed and R.H. Dave: “The effect o Molecular structure of citrates on the film properties of natural ethyl cellulose polymer” Presented at AAPS annual meeting 2008.
  • S.Khalafi, R.H.Dave and F.M.Plakogiannis:” Diffusion study of lovastatin through cellulose membrane and human cadaver skin and observing the effect of enhancers in transdermal delivery” Presented at AAPS annual meeting 2008.
  • T.Mahnaj, S.U. Ahmed, R.H. Dave and F.Plakogiannis:”Evaluate and characterize the thermal and physical properties of ethylcellulose (EC) polymer and examine the effects of various groups of plasticizers on EC film” Presented at AAPS annual meeting 2008.
  • Rutesh Dave and Robert Bellantone. Determining the interactions between ibuprofen and polymers in amorphous solidsusing dissolution data and DSC. Presented at AAPS Annual meeting. November 6th-10th 2005.
  • Mounir Mesiha, Ann Stephenson and Rutesh Dave. Characterization of Tolnaftate physical mixtures and solid dispersions separated from solid solutions with PVP, Polaxamer and Vit E TPGS. Presented at AAPS Annual meeting. November 6th- 10th, 2005.
  • Rutesh Dave and Robert Bellantone. To study water uptake of magnesium stearate, PVP and talc and to measure interaction between them using Modulated DSC. GRASP 2004, Mercer University, Atlanta, Georgia. June 6-8, 2004.
  • Rutesh Dave, L. Parthiban, J. Kowalski, W. tong and A. Royce. Development of Rheological characterization technique as a screening tool for melt extrusion processability. Presented at AAPS Annual meeting. November 7th -11th, 2004.
  • Rutesh Dave and Robert Bellantone. Kinetics of water vapor uptake by magnesium stearate, talc, Polyvinyl pyrrolidone 40,000 and blends. Presented at AAPS Annual meeting. November 7th-11th 2004.
  • Rutesh Dave, Arup Shome and Tuo Jin. Active Release solid dosage forms, rapid dissolution and solubilization for poorly soluble drugs. AAPS annual meeting and exposition, Salt Lake City, Utah. Oct 26-30, 2003.

Honors/Awards

Recipient of Newton Award (Excellence in teaching), Long Island University, 2013.
Recipient of Founders Award, Long Island University, 2011.

Research Synopsis

The majority of my research is divided into the areas mentioned above. Many drugs are developed every single day and one of the biggest challenge is to improve the solubility and permeability of the drugs. Solubility is biggest hindrance to many new molecules coming into the market. The focus of our research in this area is to understand how solubility can be improved using various techniques and theory. Powders are very crucial into developing a solid dosage form and our research focuses on understanding the intrinsic behavior of powders so that later on during the developmental work this does not become and issue. For the oral strip formulation, our laboratory focuses on new ways to incorporate drugs into a strip formulation. In many countries drinking water is an issue and if we can incorporate drugs into strip which does not require water that will help save lives of many people across the globe.