Core Facilities

Core Facilities


LIU Pharmacy and Health Sciences Core facilities offer researchers technology, tools and expertise to facilitate their research and become competitive for extramural grant funding. Core facilities are accessible across departments and divisions.



FLOW CYTOMETRY

The Flow Cytometry Core provides access to the high-performance multicolor CytoFLEX Flow Cytometry System for single tube sample and plate loader accompanied by CytExpert software for data analysis (Beckman Coulter, Life Sciences).

We provide flow cytometry training to members of the research community and students of the College of Pharmacy and Health Sciences. Investigators from other LIU-Brooklyn departments are welcome to our facility. We are dedicated to providing the best training possible to ensure the best results attainable. The technology aids in cell counting, detecting biomarkers in complex subpopulations, identification and isolation of cancer stem cells, and functional assays.

Location: Wet Lab Building, Cancer Research Center, Room 206.
Contact: Eun-Jung Park, PhD,
718-780-6062
EunJung.Park@liu.edu



LABORATORY ANIMAL FACILITY

The Laboratory Animal Facility (LAF) operates as a research support facility for the College of Pharmacy and Health Sciences and other LIU-Brooklyn departments. This facility offers housing, resources and management to provide animal-based research. Support functions include daily animal husbandry and supervision. A part-time veterinarian and veterinary technician provide assistance and training of students in addition to disease prevention, diagnosis and control. Regulatory control is by the College of Pharmacy and Health Sciences Institutional Animal Care and Use Committee (IACUC).

Location: Wet Lab Building, Rooms 316 and 317
Contact: Grazia Stagni, PhD
718-488-1231
Grazia.Stagni@liu.edu



ANALYTICAL CORE

The Analytical Core is equipped with advanced analytical instrumentation in support of pre-clinical drug development research, industrial drug development and compounding pharmacy activities. Capabilities of the Core include physico-chemical and materials characterization, solid-state properties of APIs/excipients and dosage forms, chemical characteristics, chemical stability and degradant identification and quantitation, and the manifestation of processing and environmental stress throughout processing and storage. The instrumentation enables analysis in three broad categories: chemistry and solid-state structural analyses (LC-MS, PXRD, computational software), energetics analysis (DSC/TGA, sorption, UV, FTIR), kinetic analysis (HPLC, dissolution, crystallizer), and micromeritics (particle size, microscopy).

Location: Wet Lab Building, Room 313B
Contact: Kenneth Morris, PhD
718-246-6452
Kenneth.Morris@liu.edu



MANUFACTURING CORE

The Manufacturing Core is equipped with tablet manufacturing capabilities from single station to 16 station tablet presses together with V-blender, roller compactor, fluid bed dryer (top and bottom), coating pan and a recently acquired melt extruder. This core unit will cater to the generic, brand, nutraceutical and cosmetic industry toward developing challenging products and assist in solving common problems with tablet picking, sticking and other issues. The Core will also serve as a training hub for students, pharmaceutical scientists and employees at government agencies.

Location: Wet Lab Building, 3rd Floor 
Contact: Rutesh Dave, PhD
718-488-1101
Rutesh.Dave@liu.edu



STRUCTURE-BASED MOLECULAR AND COMPUTATIONAL DRUG DESIGN CORE

The Structure-Based Molecular And Computational Drug Design Core is equipped with the Schrödinger Small Molecule Drug Discovery Suite used for in silico compound docking and analysis. Compounds can be evaluated de novo or using virtual libraries such as ZINC or Maybridge. The program suite includes built-in capabilities for molecular dynamics simulations with Desmond, residue scanning, homology model building, site map prediction, free energy perturbation (FEP) calculations, and ADME filtering. In addition to computational drug design, open source program suites such as Phenix, CCP4, COOT, XDS, and iMosfilm
are available for macromolecular x-ray crystallography.

Location: Health Sciences Building, Room 620
Contact: Kathleen Frey, PhD
718-488-1471
Kathleen.Frey@liu.edu



SMALL ANIMAL IMAGING FACILITY

The Small Animal Imaging Facility is a state-of-the-art in vivo imaging resource dedicated to small animal research. Housing the Lumina LT system (Perkin-Elmer), this lab will provide accurate anatomical and molecular bioluminescent and fluorescent imaging. The imaging modalities offer unprecedented opportunities to study in vivo small animal models of disease, providing accurate assessment of disease initiation, progression and response to therapy. The lab will work with individual investigators to design experiments, imaging protocols (BL or F), and quantification techniques to meet individual needs.

The Animal Imaging Facility will operate with three aims:

  1. To provide in vivo imaging capabilities for College of Pharmacy and Health Sciences researchers, other Brooklyn campus researchers and collaborators
  2. To train new users and students in the theory of in vivo bioluminescence and fluorescence imaging and in the operation of our instrumentation
  3. To conduct novel research examining in vivo and ex vivo imaging techniques for disease mechanisms and progression, and drug biodistribution studies

Location: Wet Lab Building, Cancer Research Center, Rooms 219
Contact: Avinash Kumar, Ph.D.
718-780-6061
Avinash.Kumar@liu.edu


CONTACT

LIU Pharmacy
John M. Pezzuto, A.B., Ph.D.
Dean