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Faculty

Sarsvat Patel

Assistant Professor of Pharmaceutics

B.Pharm., Shri BM Shah College of Pharmacy, North Gujarat University, IndiaM.Pharm., National Institute of Pharmaceutical Education and Research (NIPER), IndiaPh.D., NIPER, India

Description

Dr. Patel has received a Ph.D. in Pharmaceutics in 2010 from the National Institute of Pharmaceutical Education and Research (NIPER, India), an M. Pharm. in Pharmaceutical Technology (Formulations) from the NIPER, and a B.S in Pharmacy from the North Gujarat University, India. He joined the Division of Pharmaceutical Sciences in fall 2012 after working at the Department of Pharmaceutics, University of Minnesota, where he worked on many research projects related to preformulation, formulation development and pharmaceutical processing. He has published 15 research articles, filed 2 patent applications, worked on various industry-sponsored projects and received research grant.

He is actively involved in research areas of pharmaceutics like – (i) Pre-formulation profiling (physico-chemical characterization, solubility, permeability), (ii) Pharmaceutical material characterization (amorphous, polymorphism, pseudo-polymorphism, salt, co-crystals), (iii) Manufacturing sciences (mechanical property, tableting, granulation, flow property) and (iv) Drug delivery to improve bioavailability. The research efforts are focused to “build-the–quality” within the drug products through pharmaceutical Quality by Design (QbD) concept. Using QbD, pharmaceutical quality is assured by understanding and controlling formulation and manufacturing variables.

Dr. Patel teaches various courses in both the graduate and entry-level programs.

Specialties

Techniques/Instruments

Solid state: PXRD, DSC, MTDSC, TGA, isothermal nanocalorimetry, DVS, FTIR, microscopy (polarized/hot stage), contact angle measurement
Powder processing: Ring shear cell, instrumented tablet press, Presster, nanoindenter, texture analyzer

Preformulation/Formulation Development

• Preparation and solid state characterization of amorphous dispersions, polymorphs, salts and hydrates
• Solubility, physical stability (solid and solution state), drug-excipient compatibility studies
• Quantification of crystalline content in formulation matrix using PXRD
• Immediate/modified release oral dosage forms, self-microemulsifying drug delivery systems, micronized suspension, nanosuspension, amorphous solid dispersion, cyclodextrin complexes and spray-dried composites
• Determination of API particle size and level of critical excipients in formulation matrix

Powder Characterization and Processing

• Solids processing - Spray-drying, Roller compaction, high-shear wet granulation, tableting (direct, wet and dry granulation), milling, flow property evaluation
• Particle engineering and characterization for size, surface area, surface energy, porosity, density, adhesion/cohesion forces
• Understanding and experience of pharmaceutical unit-operations/manufacturing equipments and process modeling/data treatment using mathematical models

Publications

Patents

1. Bansal AK, Munjal B, and Patel S. Novel self-emulsifying curcumin compositions with enhanced bioavailability. PCT/IB/2009/005154: (2009).
2. Bansal AK, Munjal B, and Patel S. Novel self nano-emulsifying curcumin (curcuminoids) composition with enhanced bioavailability. Indian Patent Application No. 1776/DEL/2008: (2008).

Research Publications

3. Pawar YB, Purohit H, Valicherla GR, Munjal B, Lale SV, Patel S, Bansal AK. 2012. Novel lipid based oral formulation of curcumin: Development and optimization by design of experiments approach, Int J Pharm 436: 617-623.
4. Patel S, Kaushal AM, Bansal AK. 2011. The effect of starch paste and sodium starch glycolate on the compaction behavior of wet granulated acetaminophen formulations. J Excipients Food Chemicals 2: (3) 64-72.
5. Patel S, Dahiya S, Sun CC, Bansal AK. 2011. Understanding size enlargement and hardening of granules on tabletability of unlubricated granules prepared by dry granulation. J Pharm Sci 100: 758–766.
6. Patel S, Bansal AK. 2011. Prediction of mechanical properties of compacted binary mixtures containing high-dose poorly compressible drug. Int J Pharm 403: 109-114.
7. Munjal B, Pawar YB, Patel S, Bansal AK. 2011. Comparative oral bioavailability advantage from curcumin formulations. Drug Del Trans Res 1-10.
8. Srivastava A, Mishra S, Tandon P, Patel S, Ayala A, Bansal A, Siesler H. 2010. Molecular structure and vibrational spectroscopic analysis of clopidogrel hydrogen sulphate. J Mol Struct 964: 88-96.
9. Patel S, Kaushal AM, Bansal AK. 2010. Mechanistic investigation on pressure dependency of Heckel parameter. Int J Pharm 389: 66-73.
10. Joshi AB, Patel S, Kaushal AM, Bansal AK. 2010. Compaction studies of alternate solid forms of celecoxib. Adv Powder Technol 21: 452-460.
11. Hiwale P, Amin A, Patel S, Bansal AK. 2009. Variables affecting reconstitution behavior of cefuroxime sodium for injection. Asian J Pharm Sci 4: 23-31.
12. Alam S, Patel S, Bansal AK. 2009. Effect of sample preparation method on quantification of polymorphs using PXRD. Pharm Dev Technol 15: 452-459.
13. Patel S, Kaushal AM, Bansal AK. 2008. Compaction behavior of roller compacted ibuprofen. Eur J Pharm Biopharm 69: 743-749.
14. Hiwale P, Amin A, Patel S, Bansal AK. 2008. Reconstitution behavior of cefuroxime sodium powder for injection. Indian J Hosp Pharm 45: 121-125.
15. Patel S, Kaushal AM, Bansal AK. 2007. Effect of particle size and compression force on compaction behavior and derived mathematical parameters of compressibility. Pharm Res 24: 111-124.
16. Patel S, Kaushal AM, Bansal AK. 2007. Lubrication potential of magnesium stearate studied on instrumented rotary tablet press. AAPS PharmSciTech 8: E1-E8.
17. Patel S, Kaushal AM, Bansal AK. 2006. Compression physics in the formulation development of tablets. Crit Rev Ther Drug Carrier Syst 23: 1-65.

Lectures and Presentations

Conference Presentations - Total 19. Selected Poster presentations.

1. Patel S, Hou H, Huang Y, Zhang GGZ, Strong J, Sun CC. Assessing the effect of drug loading on mechanical properties of copovidone-based amorphous solid dispersions.
2. Patel S, Hou H, Huang Y, Zhang GGZ, Strong J, Sun CC. Mechanical properties of copovidone (PVP/VA64) amorphous solid dispersions - effects of moisture, drug and surfactants loading.
3. Patel S, Sun CC. A modernized indentation technique for measuring pharmaceutical compact hardness.
4. Patel S, Sun CC. Moisture-induced deterioration in flow properties of microcrystalline cellulose.
5. Dahiya, S., Patel S., and Bansal, A. K. Effect of altered granule morphology on inherent bonding properties of microcrystalline cellulose. In: The Fourth Asian Particle Technology Symposium (APT), September 14-16, New Delhi, India, 2009.
6. Patel S., Kaushal, A. M., and Bansal, A. K. Investigation of bonding strength and bonding capacity in structurally similar materials - The Ryshkewitch and force–displacement profiles of palmitic acid and stearic acid In: 61th Indian Pharmaceutical Congress (IPC), December 11–13, Ahmedabad, India, 2009.
7. Dahiya, S., Patel S., and Bansal, A. K. Effect of altered granule morphology on granule and compaction properties of microcrystalline cellulose. In: 61th Indian Pharmaceutical Congress (IPC), December 11–13, Ahmedabad, India, 2009.
8. Patel S., Kaushal, A. M., and Bansal, A. K. Measurement of compaction force and displacement parameters for quantification of compactability of pharmaceuticals. In: Annual Meeting and Exposition of the Controlled Release Society (CRS), July 12-16, New York, NY, USA, 2008.
9. Patel S., Kaushal, A. M., and Bansal, A. K. Micro mechanical investigation of fracture properties of roller compacted acetaminophen. In: Annual Meeting and Exposition of the Controlled Release Society (CRS), July 12-16, New York, NY, USA, 2008.
10. Patel S., Kaushal, A. M., and Bansal, A. K. Instrumented tableting press as an analytical tool to monitor precompression, main compression and ejection forces in the early formulation development of pharmaceuticals. In: 60th Indian Pharmaceutical Congress (IPC), December 12 – 14, New Delhi, India, 2008.
11. Patel S., Kaushal, A. M., and Bansal, A. K. Influence of experimental variables of true density and compact weight on evaluation of compaction behavior of pharmaceutical drug substances using Heckel model. In: 60th Indian Pharmaceutical Congress (IPC), December 12–14, New Delhi, India, 2008.

Honors/Awards

• Young Scientist Award (2007) - Department of Science and Technology, Govt. of India.
• Senior Research Fellowship (2006-07) - Department of Biotechnology, Govt. of India.
• All India 1st rank in 2004 nation-wide Graduate Aptitude Test.
• Gold Medal for standing first in pharmacy school at undergraduate level (B. Pharm.).
• International Travel Award (2008) – Council of Scientific and Industrial Research, Govt. of India.
• Chair (2007-09) American Association of Pharmaceutical Scientists (AAPS)–NIPER student chapter.
• Reviewer for the peer reviewed journals

Professional Affiliations

American Association of Pharmaceutical Scientists (AAPS)
American Association of Indian Pharmaceutical Scientists (AAiPS)
Alumni - University of Minnesota (UMN)
Alumni - National Institute of Pharmaceutical Education and Research (NIPER)

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